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Updated: Jul 6, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
Published on: July 22, 2021
Spontaneous osteonecrosis of the knee
Taj M Kattapuram1, Susan V Kattapuram
1Department of Radiology, Massachusetts General Hospital, MA, USA.
Abstract:
Spontaneous osteonecrosis of the knee presents with acute onset of severe, pain in elderly patients, usually female and usually without a history of trauma. Originally described as idiopathic osteonecrosis, the exact etiology is still debated. Evidence suggests that an acute fracture occurs as a result of chronic stress or minor trauma to a weakened subchondral bone plate. The imaging characteristics on MR reflect the age of the lesion and the symptoms. More appropriate terminology may be " subchondral insufficiency fracture of the knee" or "focal subchondral osteonecrosis".
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