Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Blood Transfusion and Agglutination

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...

Blood Transfusion

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Disorders of Erythrocytes

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...

Rh Blood Group

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Massive transfusion policy in the Netherlands, a nationwide survey.

Transfusion·2025

Same author

Comparative proteomics of erythrocyte aging in vivo and in vitro.

Journal of proteomics·2009

Same author

Red cell transfusion: how to guide our clinical practice?

Acta clinica Belgica·2009

Same author

Erythrocyte ageing in vivo and in vitro: structural aspects and implications for transfusion.

Transfusion medicine (Oxford, England)·2009

Same author

Fetal/neonatal allo-immune thrombocytopenia (FNAIT): past, present, and future.

Obstetrical & gynecological survey·2008

Same author

An unusual presentation and way to diagnose hepatocellular carcinoma.

The Netherlands journal of medicine·2004

Search research articles

Related Experiment Video

Updated: Jul 6, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Red cell transfusion in medicine: future challenges.

V M J Novotny¹

¹Department of Blood Transfusion and Transplantation Immunology (469), Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands. v.novotny@hemat.umcn.nl

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine

|March 25, 2008

Summary

Red blood cell storage causes changes that may lead to transfusion side effects like inflammation and poor oxygen delivery. Research into red cell aging during storage is key to preventing transfusion complications.

Related Experiment Videos

Last Updated: Jul 6, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Area of Science:

Transfusion Medicine
Hematology
Cellular Biology

Background:

Red blood cell transfusions can cause adverse effects, including iron overload and antibody formation.
Erythrocytes undergo significant changes during storage, termed the red cell storage lesion.
This lesion is hypothesized to involve accelerated or aberrant erythrocyte aging.

Purpose of the Study:

To understand the mechanisms behind the red cell storage lesion.
To investigate how erythrocyte aging during storage contributes to transfusion side effects.
To identify research priorities for improving red blood cell transfusion safety.

Main Methods:

This study is a review of existing literature on red blood cell storage and transfusion reactions.
Analysis of biochemical and structural changes in erythrocytes during storage.
Correlation of storage lesion characteristics with clinical transfusion outcomes.

Main Results:

The red cell storage lesion involves complex structural and biochemical alterations.
These changes can lead to endothelial damage, inflammation, and impaired microcirculation and oxygen delivery post-transfusion.
Accelerated or aberrant erythrocyte aging is implicated in the development of the storage lesion.

Conclusions:

Understanding erythrocyte fate after transfusion is crucial for preventing adverse events.
Further research focusing on the red cell storage lesion and its link to aging is essential for clinical transfusion medicine.
Targeting the storage lesion could mitigate transfusion-related complications and improve patient outcomes.