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Related Experiment Video

Updated: Jul 6, 2026

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis
10:33

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Published on: June 20, 2012

Transient neuronal correlations underlying goal selection and maintenance in prefrontal cortex.

Satoshi Tsujimoto1, Aldo Genovesio, Steven P Wise

  • 1Laboratory of Systems Neuroscience, National Institute of Mental Health, Building 49, Room B1EE17, 49 Convent Drive, MSC 4401, Bethesda, MD 20892-4401, USA. tsujimotos@mail.nih.gov

Cerebral Cortex (New York, N.Y. : 1991)
|March 25, 2008
PubMed
Summary

Prefrontal cortex neurons involved in goal selection show correlated activity. Future goal (F) cells and past goal (P) cells exhibit distinct firing patterns, aiding in goal maintenance and action transformation.

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Primate Behavior

Background:

  • Prefrontal cortex neurons play a crucial role in decision-making and goal-directed behavior.
  • Two distinct neuronal populations, future (F) cells and past (P) cells, were previously identified in the prefrontal cortex, encoding future and previous goals, respectively.

Purpose of the Study:

  • To investigate the correlated activity among pairs of F cells and P cells.
  • To understand the neural mechanisms underlying goal selection and maintenance.

Main Methods:

  • Recording neural activity from pairs of prefrontal cortex neurons in monkeys performing spatial goal selection tasks.
  • Analyzing correlated activity patterns between different types of neuronal pairs (F-F, F-P, P-P).

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Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy

Published on: June 13, 2017

Related Experiment Videos

Last Updated: Jul 6, 2026

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis
10:33

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Published on: June 20, 2012

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy
10:35

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy

Published on: June 13, 2017

Main Results:

  • F-F and F-P neuronal pairs showed significant correlations during and after future goal selection, unlike P-P pairs.
  • Correlations were stronger when monkeys switched goals compared to when they maintained a goal.
  • F-F pairs shared prospective coding and spatial tuning, while F-P pairs typically had different spatial preferences.

Conclusions:

  • Correlated activity among prefrontal cortex neurons, particularly F-F and F-P pairs, is crucial for context-dependent goal selection and maintenance.
  • These neural interactions may enhance the transformation of goal choices into actions.
  • Understanding these neuronal dynamics provides insights into the neural basis of cognitive control and decision-making.