Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Parathyroiditis in the non-obese diabetic mouse--a new finding.

J Krug¹, A J Williams, P E Beales

¹Department of Diabetes and Metabolism, St Bartholomew's Hospital, London.

The Journal of Endocrinology

|November 1, 1991

Summary

Autoimmune parathyroiditis was identified in non-obese diabetic (NOD) mice, suggesting this condition is part of the wide spectrum of autoimmunity in this diabetes model.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The psychosocial experiences of women diagnosed with PMOS in Trinidad and Tobago: a qualitative inquiry.

Women & health·2026

Same author

Development of chemical categories for per- and polyfluoroalkyl substances (PFAS) and the proof-of-concept approach to the identification of potential candidates for tiered toxicological testing and human health assessment.

Computational toxicology (Amsterdam, Netherlands)·2025

Same author

Satellite-based vertical land motion for infrastructure monitoring: a prototype roadmap in Greater Houston, Texas.

Scientific reports·2025

Same author

Feasibility study of the implementation of health promoting processes in a secondary school and ways to capture its impact on adolescent lifestyle choices.

Public health in practice (Oxford, England)·2025

Same author

Comparison of tetramethylammonium hydroxide (TMAH), trimethylsulfonium hydroxide (TMSH), and trimethylphenylammonium hydroxide (TMPAH) thermochemolysis for in situ space analysis of organic molecules in planetary environments.

Talanta·2023

Same author

Effects of COVID-19 on Vaccine-Preventable Disease Surveillance Systems in the World Health Organization African Region, 2020.

Emerging infectious diseases·2022

Area of Science:

Immunology
Endocrinology
Autoimmunity

Background:

Autoimmune polyendocrinopathy in humans involves parathyroid cell autoimmunity.
Such findings have not been previously described in animal models of polyendocrine autoimmunity.

Purpose of the Study:

To investigate the presence and characteristics of parathyroiditis in the non-obese diabetic (NOD) mouse model.

Main Methods:

Histopathological examination of parathyroid glands from NOD mice.
Immunophenotyping of infiltrating lymphocytes using L3T4 monoclonal antibody.

Main Results:

Lymphocytic infiltrations were identified in 3 out of 12 parathyroid glands studied.
The majority of infiltrating lymphocytes exhibited a helper/inducer phenotype (L3T4+).

Related Experiment Videos

Parathyroiditis was rarely accompanied by lymphocytic thyroiditis.

Conclusions:

Parathyroiditis occurs in the NOD mouse.
This finding indicates that parathyroiditis is part of the broad autoimmune spectrum in the NOD mouse model.