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Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
Published on: March 14, 2017
Parathyroiditis in the non-obese diabetic mouse--a new finding
J Krug1, A J Williams, P E Beales
1Department of Diabetes and Metabolism, St Bartholomew's Hospital, London.
The Journal of Endocrinology
|November 1, 1991
Summary
Autoimmune parathyroiditis was identified in non-obese diabetic (NOD) mice, suggesting this condition is part of the wide spectrum of autoimmunity in this diabetes model.
Area of Science:
- Immunology
- Endocrinology
- Autoimmunity
Background:
- Autoimmune polyendocrinopathy in humans involves parathyroid cell autoimmunity.
- Such findings have not been previously described in animal models of polyendocrine autoimmunity.
Purpose of the Study:
- To investigate the presence and characteristics of parathyroiditis in the non-obese diabetic (NOD) mouse model.
Main Methods:
- Histopathological examination of parathyroid glands from NOD mice.
- Immunophenotyping of infiltrating lymphocytes using L3T4 monoclonal antibody.
Main Results:
- Lymphocytic infiltrations were identified in 3 out of 12 parathyroid glands studied.
- The majority of infiltrating lymphocytes exhibited a helper/inducer phenotype (L3T4+).
- Parathyroiditis was rarely accompanied by lymphocytic thyroiditis.
Conclusions:
- Parathyroiditis occurs in the NOD mouse.
- This finding indicates that parathyroiditis is part of the broad autoimmune spectrum in the NOD mouse model.
