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Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
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Published on: November 7, 2025

Sequential treatment for recurrent localized prostate cancer.

H G Van Der Poel1, L Moonen, S Horenblas

  • 1Department of Urology, Netherlands Cancer Institute, Amsterdam, The Netherlands. h.vd.poel@nki.nl

Journal of Surgical Oncology
|March 25, 2008
PubMed
Summary
This summary is machine-generated.

Salvage radiotherapy and surgery offer similar survival rates for recurrent prostate cancer. However, salvage radiotherapy better preserves genitourinary function, with less urinary incontinence and erectile dysfunction.

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Area of Science:

  • Urology
  • Oncology
  • Radiation Oncology

Background:

  • Prostate cancer recurrence after initial treatment necessitates salvage therapy.
  • Salvage prostatectomy and salvage radiotherapy are established treatment options.

Purpose of the Study:

  • To compare the toxicity and efficacy of salvage prostatectomy versus salvage radiotherapy for prostate cancer recurrence.
  • To evaluate oncologic outcomes and genitourinary function preservation.

Main Methods:

  • Retrospective analysis of 73 patients with cT1c-T2 prostate cancer requiring salvage treatment.
  • Salvage surgery for biopsy-confirmed local recurrence with >10 years life expectancy.
  • Salvage external beam radiotherapy for PSA rise (>0.1 ng/ml) without systemic disease.

Main Results:

  • Comparable 10-year PSA-recurrence-free survival (55% vs. 44%) and prostate cancer-specific survival (93% vs. 89%) between salvage surgery and radiotherapy groups.
  • Biopsy Gleason score and pre-salvage PSA doubling time predicted PSA-recurrence-free survival.
  • Lower rates of urinary incontinence (13% vs. 56%) and erectile dysfunction (61% vs. 81%) in the salvage radiotherapy group.

Conclusions:

  • Salvage surgery and prostatectomy provide comparable oncologic outcomes for recurrent prostate cancer.
  • Salvage radiotherapy demonstrates superior preservation of genitourinary function compared to salvage surgery.