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Updated: Jul 6, 2026
Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
Published on: March 10, 2020
[Analysis of 993 cases of fetal malformations from 1999 to 2006]
Sheng-Li Li1, Xiu-Lan Chen, Shu-Yuan Ouyang
1Department of Ultrasound, Affiliated Shenzhen Maternity and Child Healthcare Hospital, Nanfang Medical University, Shenzhen, Guangdong 518028, China. lishengli63@126.com
Objective:
To study the value of prenatal ultrasound in the diagnosis of fetal malformations.
Methods:
We retrospectively analyzed the clinical data of 993 cases of neonates and induced babies with malformations who were labored in our hospital from January 1999 to October 2006.
Results:
The incidence rate of fetal malformation was 22.5 per thousand in our study group. The detection rate of prenatal ultrasound was 79.02% (1 062/1 344), among which the detection rate of the severe malformations (87.58%, 860/982) were significantly higher than that of the minor malformations (55.80%, 202/362) (P < 0.005). The false negative rate was high for the extremity malformations (39.46%) and facial malformations (31.91%), especially the acrosclerodermas, simple cleft palates, and ear deformities.
Conclusion:
Prenatal ultrasound is sensitive for fetal severe malformations, while the detection rate is low for fetal minor malformations.
