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Mos oncogene expression in human ovarian tumors
L Xerri1, C Charpin, J Hassoun
1Laboratoire d'Anatomie pathologique, Faculté de Médecine de Marseille, France.
Anticancer Research
|July 1, 1991
Summary
The mos proto-oncogene was studied in ovarian tumors. Mos transcripts were found in some ovarian carcinomas and one germ cell tumor, suggesting a potential role in these cancers.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- The mos proto-oncogene plays a role in cellular signaling pathways.
- Aberrant proto-oncogene expression is implicated in tumorigenesis.
Purpose of the Study:
- To investigate the expression of the mos proto-oncogene in various ovarian tumor types.
- To explore the potential involvement of mos proto-oncogene activation in ovarian cancer development.
Main Methods:
- In situ RNA/RNA hybridization was performed on frozen tissue sections.
- A [35S] labeled mos probe was used to detect mos transcripts.
- Tumor samples included ovarian adenocarcinomas, seminoma, immature teratoma, and benign stromal tumors.
Main Results:
- Mos transcripts were detected in three out of 15 ovarian adenocarcinomas.
- Mos transcripts were also detected in one germ cell tumor (seminoma or immature teratoma).
- No mos transcripts were detected in the benign stromal tumors.
Conclusions:
- The mos proto-oncogene is expressed in a subset of ovarian carcinomas and germ cell tumors.
- These findings suggest a potential role for mos proto-oncogene activation in the pathogenesis of these ovarian malignancies.
- Further research is warranted to elucidate the functional significance of mos proto-oncogene expression in ovarian cancer.