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Updated: Jul 6, 2026

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Efficient gene transfection with functionalised multicalixarenes.

Ruth Lalor1, Jessica L DiGesso, Anja Mueller

  • 1School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, UK.

Chemical Communications (Cambridge, England)
|March 26, 2008
PubMed
Summary
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Novel amino-functionalised multicalixarenes demonstrate low toxicity and effective DNA binding. Those with aliphatic amines are efficient gene transfection agents, showing promise for genetic therapies.

Area of Science:

  • Supramolecular Chemistry
  • Nanotechnology
  • Biotechnology

Background:

  • Multicalixarenes are macrocyclic compounds with diverse applications.
  • Gene delivery systems are crucial for genetic therapies.
  • Developing non-viral gene vectors with low toxicity is a key challenge.

Purpose of the Study:

  • To synthesize novel amino-functionalised multicalixarenes.
  • To evaluate their potential as gene transfection agents.
  • To assess their cellular toxicity and DNA binding capabilities.

Main Methods:

  • Synthesis of amino-functionalised multicalixarenes.
  • Cellular toxicity assays.
  • DNA binding studies.
  • Gene transfection efficiency evaluation.

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Last Updated: Jul 6, 2026

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Main Results:

  • Successfully synthesized novel amino-functionalised multicalixarenes.
  • Demonstrated low cellular toxicity for the synthesized compounds.
  • Confirmed effective DNA binding properties.
  • Identified multicalixarenes with aliphatic amines as efficient gene transfection agents.

Conclusions:

  • Amino-functionalised multicalixarenes are promising candidates for gene delivery.
  • The presence of aliphatic amines enhances gene transfection efficiency.
  • These compounds offer a potential low-toxicity alternative to existing gene vectors.