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Early changes in renal hemodynamics in children with diabetes: Doppler sonographic findings

Piernicola Pelliccia1, Alessandra Savino, Cristina Cecamore

  • 1Department of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini, 5, 66013 Chieti, Italy.

Journal of Clinical Ultrasound : JCU
|March 26, 2008
PubMed

Insights

Children with diabetes show elevated renal Doppler resistance index (RI) values, indicating early hemodynamic changes. This suggests a preclinical stage of diabetic nephropathy detectable by Doppler sonography.

Area of Science:

  • Pediatric Nephrology
  • Diabetology
  • Medical Imaging

Background:

  • Diabetic microvascular complications are rare in childhood but early abnormalities may exist.
  • Renal Doppler resistance index (RI) assesses blood flow in renal diseases.
  • Investigating intrarenal Doppler RI in pediatric diabetes is crucial.

Purpose of the Study:

  • To evaluate intrarenal Doppler RI in children with diabetes.
  • To compare RI in diabetic children versus healthy controls.
  • To detect early renal hemodynamic alterations in pediatric diabetes.

Main Methods:

  • Study included 42 children with diabetes and 41 healthy controls (ages 6-18).
  • All participants had normal renal function.
  • Doppler sonography measured RI in interlobular renal arteries.

Main Results:

  • Children with diabetes had significantly higher RI values (0.64 ± 0.03) than controls (0.60 ± 0.04).
  • RI positively correlated with HbA1c (P < 0.001, r = 0.42).
  • RI also correlated with diabetes duration (P < 0.05, r = 0.39).

Conclusions:

  • Doppler sonography can detect early renal hemodynamic changes in children with diabetes.
  • These changes occur without evident renal dysfunction.
  • Findings suggest a preclinical stage of diabetic nephropathy.
Abstract

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