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Updated: Jul 6, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

Optimal drinking water composition for caries control in populations.

M Bruvo¹, K Ekstrand, E Arvin

¹Dental School of Copenhagen, University of Copenhagen, Nørre Alle 20, 2200 Copenhagen N, Denmark.

Journal of Dental Research

|March 26, 2008

Summary

Calcium and fluoride in drinking water significantly reduce tooth decay (dental caries). This study found that these two minerals together explained 45% of variations in decayed, missing, and filled tooth surfaces in schoolchildren.

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Published on: March 27, 2026

Area of Science:

Dental Public Health
Environmental Chemistry
Epidemiology

Background:

Fluoride in drinking water is known to prevent dental caries.
The influence of other drinking water constituents on caries is less understood.
Oral ion interactions may affect fluoride's efficacy in caries prevention.

Purpose of the Study:

To investigate the role of various drinking water chemicals beyond fluoride in dental caries.
To identify specific ions that, in combination with fluoride, impact caries prevalence.
To explore the potential for optimizing drinking water composition for improved dental health.

Main Methods:

Analysis of 22 standard chemical variables in drinking water across 249 Danish municipalities.
Statistical analysis correlating water chemistry with dental caries data (decayed, missing, filled tooth surfaces - DMF-S) in 52,057 schoolchildren.
Iterative search and testing to identify significant predictors of DMF-S.

Main Results:

Calcium and fluoride together explained 45% of the variation in DMF-S.
Both calcium and fluoride demonstrated independent caries-reducing effects.
The combined effect of calcium and fluoride was significant in influencing dental caries levels.

Conclusions:

The impact of drinking water on dental caries is not solely attributable to fluoride.
Calcium, in conjunction with fluoride, plays a crucial role in caries prevention.
Drinking water composition, particularly calcium and fluoride levels, can be optimized for population-level caries control.