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Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

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Fluoride and casein phosphopeptide-amorphous calcium phosphate.

E C Reynolds¹, F Cai, N J Cochrane

¹Cooperative Research Centre for Oral Health Science, School of Dental Science, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Victoria 3000, Australia. e.reynolds@unimelb.edu.au

Journal of Dental Research

|March 26, 2008

Summary

Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) enhances fluoride uptake in plaque and promotes enamel remineralization. CPP-ACP combined with fluoride in toothpaste showed superior results for dental health.

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Area of Science:

Dental Science
Biomaterials Science

Background:

Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) is known to slow caries progression and remineralize enamel.
Fluoride is a key agent in preventing and reversing dental caries.

Purpose of the Study:

To evaluate CPP-ACP's efficacy in increasing fluoride incorporation into dental plaque.
To assess CPP-ACP's ability to promote enamel remineralization in an in situ setting.
To compare the effects of CPP-ACP with and without fluoride in various oral care formulations.

Main Methods:

Randomized, double-blind, cross-over studies were conducted using mouthrinses and dentifrices containing CPP-ACP and fluoride.
Mouthrinses were used for 60 seconds, three times daily for 5 days, with plaque analysis for fluoride content.
Dentifrices were used as water slurries for 60 seconds, four times daily for 14 days in an in situ model.

Main Results:

The addition of 2% CPP-ACP to a 450-ppm fluoride mouthrinse significantly enhanced fluoride incorporation into plaque.
A dentifrice with 2% CPP-ACP demonstrated remineralization comparable to a 2800-ppm fluoride dentifrice.
A formulation combining 2% CPP-ACP with 1100-ppm fluoride proved superior to all other tested formulations.

Conclusions:

CPP-ACP enhances fluoride uptake by dental plaque.
CPP-ACP-containing dentifrices show significant enamel remineralization potential, even at lower fluoride concentrations.
The combination of CPP-ACP and fluoride in dentifrices offers a superior approach to caries prevention and enamel repair.