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Updated: Jul 6, 2026

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry
Published on: July 21, 2017
The selectivity of autophagy and its role in cell death and survival
Li Yu1, Lindsey Strandberg, Michael J Lenardo
1Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-1892, USA.
Abstract:
Autophagy is a cellular process whose primary function is to degrade long-lived proteins and recycle cellular components. Beside macroautophagy, there are several forms of selective autophagy, including chaperone-mediated autophagy (CMA), cytoplasm to vacuole targeting (Cvt), pexophagy and mitophagy. In this review, we summarize what is currently known about selective autophagy, and discuss its role in cell death and survival. We also discuss possible mechanisms underlying the selectivity of macroautophagy.
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