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Corneal perforation associated with topically applied gatifloxacin

Abdulrahman Mohammed Al-Amri1

  • 1Department of Ophthalmology, College of Medicine, King Khalid University, Abha, Saudi Arabia. amaamri@hotmail.com

Cornea
|March 26, 2008
PubMed
Abstract

Insights

Gatifloxacin use for inflamed pterygium may lead to corneal perforation. Prompt management with cyanoacrylate glue and surgery is crucial for this sight-threatening complication.

Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Pharmacovigilance

Background:

  • Pterygium is a common ocular condition.
  • Inflamed pterygium requires treatment.
  • Gatifloxacin is an antibiotic used in ophthalmic preparations.

Observation:

  • A 30-year-old male patient developed corneal perforation.
  • The perforation occurred after treatment with gatifloxacin for inflamed pterygium.

Findings:

  • Discontinuation of gatifloxacin was the first step in management.
  • Corneal perforation was successfully treated with cyanoacrylate glue.
  • Subsequent pterygium excision was performed.

Implications:

  • Gatifloxacin may be associated with an increased risk of corneal perforation in patients with inflamed pterygium.
  • Ophthalmologists should exercise caution when prescribing gatifloxacin for pterygium.
  • Further research is warranted to confirm this association and elucidate the mechanism.

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