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Updated: Jul 6, 2026
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
Histologic evaluation of a cornea in a patient with apolipoprotein A-I deficiency
Yasuhiro Osakabe1, Shiro Amano, Shima Fukuoka
1Department of Pathology, Tokyo Medical University, Tokyo, Japan.
Purpose:
To report the histology of a cornea in a patient with apolipoprotein A-I (apoA-I) deficiency.
Methods:
A cornea from a patient with apoA-I deficiency was obtained by keratoplasty and examined histologically.
Results:
There were many small vesicles in the extracellular matrix throughout the corneal stroma. The vesicles were round or oval, and their diameters ranged from 200 nm to 2 microm. These histologic properties suggest that the small vesicles are lipid droplets.
Conclusions:
Myriad lipid droplets in the extracellular matrix in the corneal stroma induce diffuse corneal opacity in a patient with apoA-I deficiency.
