Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 6, 2026

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants
04:16

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants

Published on: August 5, 2021

Surface modification of titanium for load-bearing applications.

Susmita Bose1, Mangal Roy, Kakoli Das

  • 1W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA. sbose@wsu.edu

Journal of Materials Science. Materials in Medicine
|March 26, 2008
PubMed
Summary

This study enhances titanium (Ti) implants by coating them with bioactive tricalcium phosphate (TCP) and nanoscale titanium dioxide (TiO2). These modifications improve bone cell interaction and provide significant antibacterial properties for medical devices.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiple Drug Delivery Ability of Calcium Phosphate Scaffolds promotes Osteogenic Gene Expression in In Vitro Co‑culture Model.

Regenerative engineering and translational medicine·2026
Same author

ZnO-Hydroxyapatite-Coated Ti-6Al-4V With Curcumin and Ginger Extract for Load-Bearing Implants.

Journal of the American Ceramic Society. American Ceramic Society·2026
Same author

Sustained Release of Carvacrol Aldehyde from Hydroxyapatite for Osteosarcoma Inhibition.

Molecular pharmaceutics·2026
Same author

Integrated and Comprehensive Diagnostics: An Emerging Paradigm in Precision Oncology.

Cancers·2026
Same author

Ti6Al4V-Bioglass-Copper Composites for Load-Bearing Implants.

Advanced healthcare materials·2026
Same author

Understanding the Reusability of Ti6Al4V Powder in Laser Powder Bed Fusion.

Engineering science in additive manufacturing·2026

Area of Science:

  • Biomaterials Science
  • Surface Engineering
  • Nanotechnology

Background:

  • Titanium (Ti) and its alloys are widely used in load-bearing medical devices due to their mechanical properties.
  • However, their bioinert nature leads to fibrous encapsulation, limiting integration with surrounding tissues.
  • Enhancing the bioactivity and biocompatibility of titanium surfaces is crucial for improved implant performance.

Purpose of the Study:

  • To modify titanium surfaces with bioactive tricalcium phosphate (TCP) and nanoscale titanium dioxide (TiO2).
  • To enhance cell-material interactions for improved osseointegration.
  • To evaluate the antibacterial properties of the modified titanium surfaces.

Main Methods:

  • Laser-assisted coating of TCP onto titanium substrates.

Related Experiment Videos

Last Updated: Jul 6, 2026

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants
04:16

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants

Published on: August 5, 2021

  • Anodization of titanium using a mixed electrolyte (sodium fluoride, citric acid, sulfuric acid) to grow TiO2 nanotubes at room temperature.
  • Characterization of coating microstructure, hardness, and TiO2 nanotube dimensions.
  • Culturing osteoprecursor cells (OPC1) on coated surfaces to assess cell-material interactions.
  • Electrodeposition of silver (Ag) for antibacterial activity testing against Pseudomonas aeruginosa.

    • Main Results:

    • TCP coating exhibited a transition in grain structure from columnar to equiaxed and increased coating hardness from 882 +/- 67 to 1029 +/- 112 Hv with increasing TCP content.
    • TiO2 nanotubes formed with diameters of 50 nm, wall thicknesses of 15 nm, and lengths ranging from 200 nm to 1 micron, dependent on anodization time.
    • Enhanced osteoprecursor cell (OPC1) attachment and proliferation were observed on modified surfaces.
    • Silver-coated surfaces demonstrated over 99% antibacterial activity against Pseudomonas aeruginosa.

    Conclusions:

    • Surface modification of titanium with TCP and nanoscale TiO2 effectively enhances bioactivity and promotes better bone cell-material interactions.
    • The developed methods offer a promising approach for creating next-generation dental and orthopedic implants with improved osseointegration and reduced infection risk.
    • The incorporation of silver further enhances the implant's utility by providing potent antibacterial capabilities.