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Published on: January 25, 2019
Association of VEGF gene polymorphisms with diabetic retinopathy in a south Indian cohort
Satagopan Uthra1, Rajiv Raman, Bickol N Mukesh
1SN ONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.
Background:
Polymorphisms in vascular endothelial growth factor (VEGF) gene have been associated with diabetic retinopathy (DR) in various populations. A promoter polymorphism and a 3'UTR variation are studied for association with DR.
Materials And Methods:
Type 2 diabetic patients with and without retinopathy were recruited. The -634C/G and 936C/T polymorphisms were genotyped by direct sequencing and their frequencies were analyzed using relevant statistical tests.
Results:
No significant association was observed between genotypes, alleles and haplotypes of -634C/G and 936C/T polymorphisms and DR or its severity. However, C(-634)G genotype was found to increase the risk for DR in patients with microalbuminuria (OR: 8.9, 95% CI: 1.4, 58.3).
Conclusion:
Our study broadly suggests lack of association of VEGF gene polymorphisms with DR.
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