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Related Experiment Videos

Delayed hypersensitivity reaction to subcutaneous heparin.

J K Rivers1, M P Gianoutsos

  • 1Sydney Melanoma Unit, Department of Surgery, Royal Prince Alfred Hospital, Camperdown, New South Wales.

The Australian and New Zealand Journal of Surgery
|November 1, 1991
PubMed
Summary

Two women experienced skin reactions, specifically eczematous and erythematous plaques, after receiving subcutaneous preservative-free heparin injections. These reactions, indicative of delayed hypersensitivity, highlight an uncommon but important adverse effect of heparin therapy.

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Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Background:

  • Heparin is a widely used anticoagulant.
  • Adverse reactions to heparin can occur, but delayed hypersensitivity is considered uncommon.
  • Preservative-free heparin is often used to minimize potential reactions.

Observation:

  • Two patients developed localized eczematous and erythematous plaques at heparin injection sites 72-96 hours post-administration.
  • Skin lesions resolved within a week of heparin cessation.
  • Standard allergy testing (epicutaneous and in vitro) did not show a response to heparin.

Findings:

  • Both patients exhibited a delayed hypersensitivity reaction to subcutaneous heparin upon re-challenge.
  • Intradermal and subcutaneous re-challenge with heparin induced eczematous plaques within 48-96 hours.

Related Experiment Videos

  • The study identified delayed-type hypersensitivity as a potential adverse reaction to subcutaneous heparin.

    • Implications:

    • Physicians and surgeons should be aware of delayed hypersensitivity reactions to subcutaneous heparin.
    • This adverse reaction, though uncommon, can manifest as localized skin plaques.
    • Recognition of this reaction is crucial given the widespread use of heparin preparations.