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Updated: Jul 6, 2026

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model
Published on: February 17, 2019
Targeted therapies for patients with germ cell tumors
Martin H Fenner1, Gernot Beutel, Viktor Grünwald
1Hannover Medical School, Department of Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany. fenner.martin@mh-hannover.de
Background:
Patients with advanced germ cell tumors can be cured with cisplatin-based chemotherapy but the outcome remains unsatisfactory for patients with relapsed disease. Targeted therapies have changed the standard of care for many advanced solid tumors.
Objective:
To identify clinically available drugs that have the potential as targeted therapies in germ cell tumors.
Methods:
A literature search was carried out for expression and mutation status of receptor tyrosine kinases in germ cell tumors, also a literature and clinical trial database search for completed and ongoing clinical trials with targeted therapies in germ cell tumors.
Results/Conclusions:
c-KIT is mutated in some seminomas and bilateral germ cell tumors. Several case reports and small clinical trials with trastuzumab, thalidomide and imatinib were identified and clinical trials with sunitinib and bevacizumab are ongoing. We expect an increased use of targeted therapies in advanced germ cell tumors in the next few years.
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