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Related Concept Videos

Cytoskeletal Linker Proteins - Plakins01:09

Cytoskeletal Linker Proteins - Plakins

Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Role of Septins01:02

Role of Septins

Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...

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Related Experiment Video

Updated: Jul 6, 2026

Purification of the Dendritic Filopodia-rich Fraction
11:51

Purification of the Dendritic Filopodia-rich Fraction

Published on: May 2, 2019

Neuropilins: structure, function and role in disease.

Caroline Pellet-Many1, Paul Frankel, Haiyan Jia

  • 1Centre for Cardiovascular Science and Medicine, Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, UK.

The Biochemical Journal
|March 28, 2008
PubMed
Summary
This summary is machine-generated.

Neuropilins (NRPs) are co-receptors involved in axonal guidance and blood vessel formation. While their roles in development and cancer are known, the precise molecular mechanisms regulating cellular functions via NRPs remain unclear.

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Last Updated: Jul 6, 2026

Purification of the Dendritic Filopodia-rich Fraction
11:51

Purification of the Dendritic Filopodia-rich Fraction

Published on: May 2, 2019

Area of Science:

  • Molecular and Cellular Biology
  • Developmental Biology
  • Cancer Biology

Background:

  • Neuropilins (NRPs) function as co-receptors for class 3 semaphorins and vascular endothelial growth factor (VEGF) family members.
  • NRPs lack intrinsic signaling capabilities, mediating responses through complexes with receptors like plexins and VEGFR2.
  • Mutant mouse studies highlight NRP1's essential role in neuronal and cardiovascular development, and NRP2's role in neuronal patterning and lymphangiogenesis.

Purpose of the Study:

  • To investigate the broader biological roles of NRPs beyond their established functions.
  • To explore the involvement of NRPs in various physiological and disease-related contexts, particularly in cancer.
  • To elucidate the uncertain aspects of cellular function regulation by NRPs and the molecular mechanisms underlying their ligand interactions.

Main Methods:

  • Analysis of existing literature on neuropilins and their ligands.
  • Review of mutant mouse studies detailing NRP functions.
  • Examination of findings related to NRP expression in tumor cell lines and neoplasms.

Main Results:

  • NRPs are implicated in tumor growth and vascularization, with high expression in various tumors.
  • Recent findings suggest additional biological roles for NRPs in diverse physiological and disease settings.
  • Significant knowledge gaps exist regarding the regulation of cellular functions by NRPs and their molecular mechanisms.

Conclusions:

  • Neuropilins play critical roles in development and are increasingly recognized for their involvement in cancer.
  • Further research is needed to understand the complex molecular mechanisms by which NRPs regulate cellular functions and interact with their ligands.
  • Clarifying these mechanisms is crucial for understanding NRPs' diverse biological roles and potential therapeutic applications.