Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lithium augmentation in antidepressant-resistant patients. A quantitative analysis.

M P Austin1, F G Souza, G M Goodwin

  • 1Edinburgh University Department of Psychiatry, Royal Edinburgh Hospital.

The British Journal of Psychiatry : the Journal of Mental Science
|October 1, 1991
PubMed
Summary

Lithium augmentation significantly improves outcomes for patients with treatment-resistant depression. This meta-analysis shows lithium reduces the odds of remaining ill by 56-95%, though optimal treatment duration requires further study.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Actigraphic patterns, impulsivity and mood instability in bipolar disorder, borderline personality disorder and healthy controls.

Acta psychiatrica Scandinavica·2020
Same author

Teschovirus and other swine and human enteric viruses in Brazilian watersheds impacted by swine husbandry.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]·2019
Same author

Vitamin D, bone mineral density and risk of fracture in people with intellectual disabilities.

Journal of intellectual disability research : JIDR·2018
Same author

Re-medicalizing the care of patients with schizophrenia?

L'Encephale·2018
Same author

Variability in phase and amplitude of diurnal rhythms is related to variation of mood in bipolar and borderline personality disorder.

Scientific reports·2018
Same author

Biochemical and genetic predictors and correlates of response to lamotrigine and folic acid in bipolar depression: Analysis of the CEQUEL clinical trial.

Bipolar disorders·2017

Area of Science:

  • Psychiatry and Pharmacology
  • Clinical Neuroscience

Background:

  • Treatment-resistant depression (TRD) poses a significant clinical challenge.
  • Standard antidepressant monotherapy is ineffective for a substantial proportion of patients.
  • Augmentation strategies are crucial for managing refractory mood disorders.

Purpose of the Study:

  • To quantitatively assess the efficacy of lithium augmentation in acute treatment of TRD.
  • To determine the effect size of lithium in patients unresponsive to standard antidepressants.
  • To synthesize evidence from controlled trials on lithium's role in TRD.

Main Methods:

  • Meta-analysis of controlled trials using the Mantel-Haenszel method.
  • Calculation of pooled odds ratio to measure effect size.

Related Experiment Videos

  • Inclusion criteria focused on minimizing bias in treatment-resistant depression studies.

    • Main Results:

    • A statistically significant effect favoring lithium augmentation was observed.
    • The pooled odds ratio was 0.146 (95% CI: 0.05-0.44).
    • Lithium treatment reduced the odds of remaining ill by 56% to 95%.

    Conclusions:

    • Lithium augmentation is an effective strategy for the acute treatment of TRD.
    • Evidence supports the use of lithium in patients failing initial antidepressant trials.
    • Further research is needed to establish optimal duration for sustained response in TRD.