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[Soluble CD23: cytokine actives on human hematopoietic precursors]
M D Mossalayi1, A H Dalloul, P Debré
1Laboratoire d'Immunologie Cellulaire et Tissulaire, CNRS URA 625, Hôpital Pitié-Salpêtrière, Paris, France.
Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1991
Abstract:
We report herein the effect of soluble CD23 (sCD23) on the differentiation of early lymphoid and myeloid human precursors. CD23 is known as a low affinity receptor for IgE. In addition, our results show that sCD23 in synergy with IL1 has a potent activity on the maturation of prothymocytes and the proliferation of multipotential normal and leukemic myeloid precursors.