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[Stimulation of calcium intake by growth-hormone-releasing-hormone in GH3 cells]
1Laboratoire de Neurophysiologie, CNRS URA 1200, Université de Bordeaux II.
Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1991
Abstract:
The effect of GH-RH in the intra-cytosolic free Ca2+ concentration was studied in GH3 cells. To this end, we have used microspectrofluorimetry performed on single cells. We show that 60% of cells respond to a brief application of 100 nM GH-RH by an increase of their [Ca2+]i (mean increase 100% over basal values). This response which is blocked by calcium channel inhibitors results from an increased influx of Ca2+ ions from the external medium.