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Related Concept Videos

Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis01:35

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis And Cytokinesis01:35

Mitosis And Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Anaphase A and B01:39

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Microtubules form through the end-to-end polymerization of tubulin heterodimers. Kinetochore microtubules originate from the spindle poles, and their plus-ends connect with the kinetochores on sister-chromatids. Ndc80 protein complexes, present on the kinetochore, form low-affinity links with the plus end of these kinetochore microtubules.
Plus-end depolymerization releases tubulin heterodimers from the terminal region of the microtubule. As tubulin subunits are lost, the Ndc80 complexes detach...
Anaphase A and B01:39

Anaphase A and B

Microtubules form through the end-to-end polymerization of tubulin heterodimers. Kinetochore microtubules originate from the spindle poles, and their plus-ends connect with the kinetochores on sister-chromatids. Ndc80 protein complexes, present on the kinetochore, form low-affinity links with the plus end of these kinetochore microtubules.
Plus-end depolymerization releases tubulin heterodimers from the terminal region of the microtubule. As tubulin subunits are lost, the Ndc80 complexes detach...

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Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
11:19

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast

Published on: February 20, 2017

Cytokinesis: catch and drag.

Mithilesh Mishra1, Snezhana Oliferenko

  • 1Temasek Life Sciences Laboratory, 117604 Singapore.

Current Biology : CB
|March 28, 2008
PubMed
Summary
This summary is machine-generated.

In fission yeast, membrane-bound nodes with myosin and formin assemble into an actomyosin ring. This ring is formed via a

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Area of Science:

  • Cell biology
  • Biochemistry
  • Molecular biology

Background:

  • Actomyosin ring assembly is crucial for cell division.
  • Fission yeast is a model organism for studying cell division.
  • Previous models proposed different mechanisms for actomyosin ring formation.

Purpose of the Study:

  • To elucidate the mechanism of actomyosin ring assembly in fission yeast.
  • To investigate the role of membrane-bound nodes in ring formation.
  • To understand the 'search-and-capture' model in this context.

Main Methods:

  • Live-cell imaging of fission yeast.
  • Fluorescence microscopy to track protein dynamics.
  • Genetic manipulation to study protein function.

Main Results:

  • Identified membrane-bound nodes containing myosin and formin.
  • Observed these nodes being pulled together to form a ring.
  • Provided evidence supporting the 'search-and-capture' mechanism.

Conclusions:

  • The 'search-and-capture' mechanism is a key driver of actomyosin ring assembly in fission yeast.
  • Membrane-bound nodes play a critical role in organizing the contractile ring.
  • This mechanism ensures efficient and accurate formation of the division machinery.