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Changes in plasmaconcentration of ANP and aldosterone in normal pregnancy and pregnancy complicated by pre-eclampsia
A L Mikkelsen1, G Schütten, U Asping
1Department of Obstetrics and Gynecology, Hvidrove Hospital, University of Copenhagen, Denmark.
Changes in plasmaconcentration of ANP in normal pregnancy and pregnancy complicated by pre-eclampsia were examined and compared to non-pregnant controls. The maternal plasma concentration increased gradually during normal pregnancy but values did not deviate significantly from non-pregnant women. A further increase was demonstrated post partum. In pre-eclampsia maternal plasma ANP levels increased significantly compared with normal gravida at the same gestational age and non-pregnant controls. After delivery ANP decreased significantly. Non correlation between ANP and aldosterone were found in either normal pregnancy nor pregnancy complicated by pre-eclampsia. It is not yet clear how important ANP is for the regulation of blood pressure and sodium and water balance during normal pregnancy and pregnancy complicated by pre-eclampsia.
Changes in plasmaconcentration of ANP in normal pregnancy and pregnancy complicated by pre-eclampsia were examined and compared to non-pregnant controls. The maternal plasma concentration increased gradually during normal pregnancy but values did not deviate significantly from non-pregnant women. A further increase was demonstrated post partum. In pre-eclampsia maternal plasma ANP levels increased significantly compared with normal gravida at the same gestational age and non-pregnant controls. After delivery ANP decreased significantly. Non correlation between ANP and aldosterone were found in either normal pregnancy nor pregnancy complicated by pre-eclampsia. It is not yet clear how important ANP is for the regulation of blood pressure and sodium and water balance during normal pregnancy and pregnancy complicated by pre-eclampsia.