Related Experiment Video
Updated: Jul 6, 2026
06:59
A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection
Published on: February 2, 2022
Growth after renal transplantation
Jérôme Harambat1, Pierre Cochat
1Département de Pédiatrie and Inserm U820, Hôpital Edouard-Herriot and Université Claude-Bernard Lyon 1, Lyon, France.
Pediatric Nephrology (Berlin, Germany)
|March 28, 2008
Summary
Children with chronic kidney disease often experience impaired growth. Renal transplantation may not fully restore height due to pre-transplant growth delays and post-transplant factors affecting growth.
Area of Science:
- Pediatric Nephrology
- Endocrinology
- Transplantation Medicine
Background:
- Chronic renal insufficiency severely impairs growth in children.
- Short stature negatively impacts quality of life and self-esteem in pediatric patients.
- Achieving normal adult height is a critical goal for pediatric renal transplant recipients.
Purpose of the Study:
- To investigate factors influencing final height in pediatric renal transplant recipients.
- To identify challenges in achieving target height post-transplantation.
- To outline management strategies for growth retardation in this population.
Main Methods:
- Analysis of longitudinal growth data in pediatric renal transplant recipients.
- Evaluation of the impact of age at transplantation, allograft function, and steroid exposure on growth.
- Review of current management protocols for growth failure.
Main Results:
- Most renal transplant recipients do not reach their calculated target height.
- Post-transplant catch-up growth is often insufficient to overcome pre-transplant growth deficits.
- Growth hormone/insulin-like growth factor axis is negatively affected by allograft function and steroid use.
Conclusions:
- Final height in pediatric renal transplant recipients is influenced by multiple factors beyond successful transplantation.
- Comprehensive management including nutrition, metabolic correction, bone health, steroid minimization, and growth hormone therapy is essential.
- Optimizing growth remains a significant challenge requiring a multi-faceted approach.
Related Concept Videos
01:26Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
01:16Kidney Transplant III: Nursing Management
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:29Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
01:30Continuous Renal Replacement Therapy
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...