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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

Graft loss in three patients with donor-specific antibody (DSA)

Y Qasi1, M Hermes, J Cicciarelli

  • 1Department of Medicine and Metic Transplantation Lab, USC Keck School of Medicine.

Clinical Transplants
|March 28, 2008
PubMed

Insights

Donor-specific antibodies (DSA) are linked to transplant dysfunction and graft loss. Monitoring DSA in genetic testing can assess plasmapheresis effectiveness, aiding transplant outcomes.

Area of Science:

  • Immunology
  • Transplantation Medicine
  • Nephrology

Background:

  • Donor-specific antibodies (DSA) are a significant concern in solid organ transplantation.
  • Graft dysfunction and loss are major challenges impacting long-term transplant success.

Observation:

  • Patients presenting with graft dysfunction and loss were found to have donor-specific antibodies.
  • Flow PRA (Panel Reactive Antibody) measurements did not show a correlation with transplant dysfunction in this cohort.

Findings:

  • Donor-specific antibodies (DSA) were strongly associated with both transplant dysfunction and subsequent graft loss.
  • In genetic testing (GT), monitoring DSA levels proved effective in evaluating the efficacy of plasmapheresis treatments.

Implications:

  • DSA monitoring is crucial for managing transplant recipients and predicting graft survival.
  • Plasmapheresis, when monitored via DSA, shows potential as a therapeutic strategy for antibody-mediated rejection.
  • Further research into DSA and its management is warranted to improve long-term transplant outcomes.

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