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Related Concept Videos

Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...

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Articles linked to this work by shared authors, journal, and citation graph.

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Initial lymphatics--morphology and function of the endothelial cells.

Lymphology·2003
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The sublingua and tongue of Tupaia (Scandentia, Mammalia): a scanning electron microscope study.

Folia primatologica; international journal of primatology·1993
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The stimulation of arachidonic acid metabolism by organic lead and tin compounds in human HL-60 leukemia cells.

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Related Experiment Video

Updated: Jul 6, 2026

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

Open interfaces in initial lymphatics: a methodological artifact?

H Zöltzer1

  • 1Department of Cell Biology, Division Lymphology, University of Kassel, Germany. zoeltzer@uni-kassel.de

Lymphology
|March 28, 2008
PubMed
Summary

Previous research suggested open interfaces in lymphatic pathways. However, new findings reveal these structures are often methodological artifacts, not true lymphatic entrances.

Area of Science:

  • Lymphology
  • Anatomy
  • Histology

Background:

  • Initial lymphatics are crucial for tissue fluid balance.
  • Previously described
  • open interfaces
  • in organs like the tongue, mesentery, and uterus were thought to be lymphatic entry points.
  • These were proposed to function as pressure relief valves.

Purpose of the Study:

  • To re-evaluate the nature of previously identified
  • open interfaces
  • in the lymphatic system.
  • To determine if these structures represent true lymphatic pathways or artifacts.

Main Methods:

  • Utilized advanced lymphology research techniques.
  • Critically analyzed previous methodologies including interstitial and retrograde lymphatic fillings.

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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

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Last Updated: Jul 6, 2026

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

  • Examined endothelium-lined structures connecting initial lymphatics to the interstitial space.

    • Main Results:

    • Demonstrated that most previously identified "open interfaces" are methodological artifacts.
    • Challenged the concept of these structures as additional entrances to initial lymphatics.
    • Re-evaluated the functional significance of these observed structures.

    Conclusions:

    • The existence of
    • open interfaces
    • as described by previous authors is largely due to methodological limitations.
    • This finding necessitates a re-evaluation of lymphatic system entry mechanisms.
    • Further research in basic lymphology is essential for accurate anatomical and functional understanding.