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Updated: Jul 6, 2026
13:41
Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
HPV genotypes concordance between sex partners.
M Benevolo1, M Mottolese, F Marandino
1Pathology Department, Regina Elena Cancer Institute, Rome, Italy.
Journal of Experimental & Clinical Cancer Research : CR
|March 28, 2008
Summary
This case report shows a stable Italian couple shared five Human Papillomavirus (HPV) genotypes. The findings support the sexual transmission of HPV infection between partners.
Area of Science:
- Virology
- Genitourinary Medicine
- Epidemiology
Background:
- Human Papillomavirus (HPV) infection is a common sexually transmitted infection.
- Understanding HPV transmission dynamics is crucial for prevention and management.
- Genotype concordance in sexual partners can provide insights into transmission patterns.
Observation:
- A stable Italian sexual couple presented with shared HPV genotypes in genital samples.
- The female partner had vulvar condylomatosis and tested positive for high-risk HPV DNA.
- Despite HPV positivity, the female partner's Pap test and colposcopy were negative.
Findings:
- Five specific HPV genotypes (6, 16, 53, 73, and 84) were detected in both partners' genital scrapings.
- The high degree of genotype concordance suggests a non-incidental occurrence.
- PCR-based assays confirmed the presence of these identical HPV genotypes.
Implications:
- The observed genotype concordance strongly supports the hypothesis of sexual transmission of genital HPV types.
- This case highlights the importance of considering partner status in HPV management.
- Further research into HPV transmission within stable sexual partnerships is warranted.
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