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Updated: Jul 6, 2026
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
[Effect of indoleamine 2,3-dioxygenase on transplantation immunity]
Xiaohong Duan1, Pengcheng Cui, Xun Jiang
1Department of Otolaryngology, Tangdu Hospital, Fourth Military Medical University, Xi'an Shaanxi, 710038, P.R. China.
Objective:
To review the research progress of possible mechanism of indoleamine 2, 3-dioxygenase (IDO) in immunological regulation and function of transplantation immunity.
Methods:
The advances in the IDO location, immunological regulatory mechanism and function of transplantation immunity were introduced based on the recent related literature.
Results:
IDO played an immunoregulatory role by locally depleting tryptophan in tissue microenvironment which resulted in immunosuppression of allogeneic T-cell proliferation. IDO cDNA was delivered to chromosome in interesting cells by gene transfection and stimulated to express, which was associated with a prolongation in allograft survival in vivo.
Conclusion:
IDO offers a new way in transplantation immunity, and this provid novel method for elevating allograft survival rate.
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