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Related Experiment Videos

[Severe methotrexate poisoning].

G Troché1, P Sacquin, A Achkar

  • 1Service de Réanimation médicale, Hôpital Raymond Poincaré, Garches.

Presse Medicale (Paris, France : 1983)
|November 2, 1991
PubMed
Summary
This summary is machine-generated.

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Methotrexate toxicity, though rare, is severe, affecting multiple organs. Prompt diagnosis and supportive care, including folinic acid, can lead to full recovery.

Area of Science:

  • Oncology
  • Pharmacology
  • Toxicology

Background:

  • Methotrexate (MTX) is a crucial chemotherapeutic agent.
  • MTX toxicity can manifest as severe, multi-organ damage.
  • Early recognition and intervention are vital for patient outcomes.

Observation:

  • Observed severe MTX toxicity including gastrointestinal ulcerations, necrotizing enteritis, erythroderma, bone marrow aplasia, interstitial pneumonia, hepatitis, and renal failure.
  • Toxicity is exacerbated by pre-existing renal impairment and inadequate folinic acid (leucovorin) administration.
  • Diagnosis relies on serum MTX assays, interpreted considering assay methodology and timing post-administration.

Findings:

  • The reported case demonstrated the potential for complete regression of multivisceral pathology secondary to MTX toxicity.

Related Experiment Videos

  • Treatment strategies involve symptomatic management, including forced alkaline diuresis.
  • Parenteral folinic acid administration is a cornerstone of managing MTX overdose and toxicity.

    • Implications:

    • Highlights the critical need for vigilant monitoring of patients receiving methotrexate.
    • Emphasizes the importance of appropriate folinic acid rescue protocols.
    • Underscores that severe methotrexate toxicity, while life-threatening, can be reversible with timely and comprehensive medical intervention.