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Histological Quantification of Chronic Myocardial Infarct in Rats
Published on: December 11, 2016
The relationship between left ventricular ejection fraction and infarct size assessed by MRI
Martin Ugander1, Björn Ekmehag, Håkan Arheden
1Cardiac MR Group, Department of Clinical Physiology, Lund University Hospital, Lund, Sweden.
Scandinavian Cardiovascular Journal : SCJ
|March 28, 2008
Summary
Magnetic resonance imaging (MRI) quantifies left ventricular ejection fraction (LVEF) and infarct size in ischemic heart disease (IHD). Infarct size predicts maximum LVEF, aiding dysfunction index calculation in IHD patients.
Area of Science:
- Cardiology
- Medical Imaging
- Heart Disease Research
Background:
- Ischemic heart disease (IHD) significantly impacts left ventricular ejection fraction (LVEF).
- Accurate assessment of myocardial damage and function is crucial for patient management in IHD.
Purpose of the Study:
- To investigate the relationship between infarct size and LVEF in IHD patients using MRI.
- To establish a dysfunction index based on infarct size and maximal achievable LVEF.
Main Methods:
- Quantified LVEF and infarct size in 149 chronic IHD patients via MRI.
- Defined dysfunction index as maximal possible LVEF minus measured LVEF.
Main Results:
- Established the formula: maximal LVEF = 72.2 - (1.18 * infarct size).
- The study population showed a mean dysfunction index of 20, with 74% having an index >10 and 44% >20.
Conclusions:
- MRI-derived infarct size can estimate maximal LVEF and a dysfunction index in IHD.
- The dysfunction index distribution suggests significant viable but dysfunctional myocardium, warranting further research into its predictive value for revascularization outcomes.
