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High triglyceride level is associated with severe coronary artery disease in hypertensive subjects

Chun-Yen Chen1, Chii-Min Hwu, Ming-Wei Lin

  • 1Cardiovascular Division, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan.

Scandinavian Cardiovascular Journal : SCJ
|March 28, 2008
PubMed

Insights

High triglyceride levels are strong indicators of severe coronary artery disease (CAD) in hypertensive patients. This finding helps physicians make better treatment decisions for cardiovascular health.

Area of Science:

  • Cardiology
  • Clinical Lipidology

Background:

  • The role of triglycerides (TG) in coronary artery disease (CAD) extent among hypertensive individuals was previously uncertain.
  • Hypertension is a significant risk factor for cardiovascular disease, necessitating a clearer understanding of associated lipid profiles.

Purpose of the Study:

  • To investigate the association between triglyceride levels and the extent of coronary artery disease in hypertensive patients.
  • To determine if triglyceride levels can serve as a predictive marker for CAD severity in this population.

Main Methods:

  • A cohort of 821 hypertensive patients undergoing coronary angiography was analyzed.
  • Multiple logistic regression was employed to assess the relationship between triglyceride levels (categorized as <150 mg/dl vs. ≥150 mg/dl) and CAD extent, with adjustments for other cardiovascular risk factors.
  • Low high-density lipoprotein (HDL) levels were also considered in a specific lipid subgroup analysis.

Main Results:

  • Patients with severe CAD exhibited higher triglyceride levels compared to those with no or minimal CAD.
  • Adjusted odds ratios indicated a significantly higher likelihood of severe CAD in patients with high triglyceride levels (OR=5.20 in all patients; OR=7.51 in the lipid group).

Conclusions:

  • Elevated triglyceride levels are potent clinical markers for increased coronary artery disease extent in hypertensive patients.
  • These findings hold potential clinical significance for guiding therapeutic strategies and patient management in cardiology.
Abstract

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