Related Experiment Video
Updated: Jul 6, 2026
10:27
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
[Celiac disease associated with antiphospholipid syndrome]
1Servicio de Gastroenterología. Hospital Español de Mendoza. Argentina. arturo.jorge@speedy.com.at
Revista Espanola De Enfermedades Digestivas
|March 28, 2008
Summary
Celiac disease may be linked to antiphospholipid syndrome, a condition causing blood clots and fetal death. This association suggests antiphospholipid syndrome could explain fetal loss in celiac disease patients.
Area of Science:
- Immunology
- Gastroenterology
- Obstetrics
Background:
- Celiac disease is an immune-mediated disorder.
- Antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy complications.
- Few cases report an association between celiac disease and APS.
Observation:
- Case 1: A 26-year-old female with celiac disease experienced fetal death and later had elevated anticardiolipin antibodies.
- Case 2: A 48-year-old female with celiac disease presented with recurrent thrombosis and later showed elevated IgM anticardiolipin antibodies.
- Case 3: A 38-year-old female with celiac disease had spontaneous abortions and a transient ischemic attack, with elevated IgM anticardiolipin antibodies.
Findings:
- Elevated anticardiolipin antibodies (IgG and/or IgM) were observed in all three cases.
- Recurrent thrombosis and/or fetal death were present in all cases.
- Celiac disease diagnosis preceded the manifestation of APS symptoms in all reported cases.
Implications:
- The findings suggest a potential link between celiac disease and antiphospholipid syndrome.
- APS may be an underlying cause of fetal death in women with celiac disease.
- Further research is warranted to explore the etiological relationship and clinical management.
Related Concept Videos
01:17Gastritis-II: Pathophysiology
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
01:25Inflammatory Bowel Disease III: Crohn's Disease
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
01:30Other Disorders of Digestive System
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
01:21Chronic Pancreatitis II: Pathophysiology
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
01:17Chronic Bowel Disorders: Introduction
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:21Acute Pancreatitis II: Pathophysiology
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...