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[Captopril-induced changes in renal flow: evaluation using Doppler echography].

F Pretolesi1, L E Derchi, G Crespi

  • 1Istituto di Radiologia, Università di Genova.

Archivio Italiano Di Urologia, Nefrologia, Andrologia : Organo Ufficiale Dell'Associazione Per La Ricerca in Urologia = Urological, Nephrological, and Andrological Sciences
|June 1, 1991
PubMed
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Captopril, an angiotensin antagonist, significantly increases renal blood flow velocity in both systolic and diastolic phases. Duplex Doppler sonography confirmed these changes without altering the resistive index in healthy subjects.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Medical Imaging

Background:

  • Angiotensin antagonists are known to increase renal blood flow.
  • Understanding the precise hemodynamic effects of these drugs is crucial for patient management.

Purpose of the Study:

  • To investigate the impact of Captopril on renal blood flow velocity using duplex Doppler sonography.
  • To quantify changes in peak systolic and diastolic velocities and the resistive index.

Main Methods:

  • Oral administration of 50 mg Captopril to 17 subjects without hypertension.
  • Duplex Doppler sonography to measure renal blood flow velocity at the hilum and arcuate arteries.
  • Calculation of the resistive index (RI).

Main Results:

Related Experiment Videos

  • Significant increases in both peak systolic and diastolic blood flow velocities were observed.
  • These increases occurred at both the renal hilum and arcuate arteries.
  • No significant variation in the resistive index (RI) was detected.

Conclusions:

  • Duplex Doppler sonography effectively demonstrates Captopril-induced increases in renal blood flow velocity.
  • The drug affects the entire Doppler wave, impacting both systolic and diastolic flow without altering vascular resistance.