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[Acquired cystic kidney disease among hemodialysis patients: echographic and clinical study]
L Baldrati1, B Balbi, A Rocchi
1Servizio di Nefrologia e Dialisi, Laboratorio Analisi Ospedale M. Bufalini, Cesena.
Insights
Chronic hemodialysis patients frequently develop acquired cystic kidney disease (ACKD). The severity of ACKD and associated symptoms like abdominal pain increase with longer dialysis duration.
Area of Science:
- Nephrology
- Radiology
Background:
- Acquired cystic kidney disease (ACKD) is a common complication in patients undergoing long-term hemodialysis.
- The relationship between the duration of hemodialysis and the characteristics of ACKD requires further elucidation.
Purpose of the Study:
- To investigate the prevalence and ultrasonographic features of ACKD in patients on chronic hemodialysis.
- To determine the correlation between the duration of hemodialysis and the grade, number, size, and extent of renal cysts.
- To explore the association between ACKD and hemoglobin levels, as well as clinical symptoms.
Main Methods:
- Ultrasonographic evaluation was performed on 56 patients undergoing chronic hemodialysis.
- ACKD was defined as the presence of at least 3 cysts per kidney.
- Statistical analysis was used to assess correlations between dialysis duration, cyst characteristics, ACKD grade, hemoglobin levels, and symptoms.
Main Results:
- 64% (36 out of 56) of patients had ACKD.
- The number, size, and extent of renal cysts showed a significant positive correlation with the duration of hemodialysis (in months).
- A significant positive correlation was observed between the grade of ACKD and hemoglobin levels. Abdominal pain was also significantly associated with ACKD, while hemorrhage and neoplasm were not observed.
Conclusions:
- ACKD is highly prevalent in patients on chronic hemodialysis.
- The progression of ACKD, characterized by increased cyst burden, is directly related to the duration of hemodialysis.
- ACKD is associated with anemia (lower Hb) and abdominal pain in hemodialysis patients.
Abstract:
Thirty-six of 56 (64%) patients on chronic hemodialysis for 1 to 194 months were found to have ACKD (at least 3 cysts per kidney) by means of ultrasonographic evaluation. The number, size and extent of cysts were positively and significantly correlated with the months on hemodialysis. There was also a significant positive correlation between grade of ACKD and Hb. Moreover there was a significant positive association of abdominal pain; none had suffered from hemorrhage or neoplasm.