MausDB: an open source application for phenotype data and mouse colony management in large-scale mouse phenotyping...

Area of Science:

• Genomics
• Bioinformatics
• Animal Models

Background:

• High-throughput mouse phenotyping generates vast datasets requiring robust management.
• Centralized storage and integrated management of mouse phenotype, genotype, and metadata are crucial for functional genomics.
• Developing tailored database solutions can be resource-intensive for individual research groups.

Purpose of the Study:

• To present MausDB, a web-based database application for the German Mouse Clinic.
• To provide a comprehensive system for mouse colony management, phenotyping workflow scheduling, and data management.
• To offer a flexible and user-friendly solution for storing and accessing functional genomics data.

Main Methods:

• Development of a web-based database application (MausDB).
• Integration of standard mouse colony management features.
• Inclusion of phenotyping workflow scheduling and result data management.
• Linking phenotype data with genotype, metadata, and external databases using open standards.

Main Results:

• MausDB integrates colony management, phenotyping workflows, and result data.
• The system links diverse data types, enabling comprehensive analysis and data mining.
• MausDB is built on open standards, ensuring a lean and user-friendly experience.

Conclusions:

• MausDB is suitable for large-scale, high-throughput phenotyping facilities and smaller projects.
• The system is successfully implemented as the primary data management tool at the German Mouse Clinic and other facilities.
• MausDB is offered as open-source software to the scientific community for well-structured and accessible data storage.