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Updated: Jul 6, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

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Published on: October 12, 2017

Why is HDL functionally deficient in type 2 diabetes?

Anatol Kontush¹, M John Chapman

¹INSERM Unité 551, Pavillon Benjamin Delessert, Hôpital de Pitié, 83 boulevard de l'Hôpital, 75651 Paris Cedex 13, France. kontush@chups.jussieu.fr

Current Diabetes Reports

|March 28, 2008

Summary

This summary is machine-generated.

Type 2 diabetes impairs high-density lipoprotein (HDL) function through triglyceride enrichment and apolipoprotein A-I changes. Targeting hypertriglyceridemia is key to restoring HDL

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An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

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Published on: April 26, 2019

Area of Science:

Cardiovascular Science
Metabolic Disorders
Lipid Metabolism

Background:

High-density lipoprotein (HDL) particles possess atheroprotective properties.
These protective functions are often compromised in individuals with type 2 diabetes.

Purpose of the Study:

To elucidate the mechanisms behind functionally deficient HDL in type 2 diabetes.
To identify the primary drivers of HDL dysfunction in this patient population.

Main Methods:

Analysis of HDL composition, including triglyceride and cholesteryl ester content.
Assessment of apolipoprotein A-I conformation.
Evaluation of HDL-associated glycation and oxidative modifications.

Main Results:

HDL particles in type 2 diabetes show enrichment in triglycerides and depletion in cholesteryl esters.
Conformational alterations of apolipoprotein A-I are observed.
Glycation and oxidative modifications affect HDL-associated proteins and lipids.

Conclusions:

Hypertriglyceridemia is a major factor in the functional decline of HDL in type 2 diabetes.
Compositional changes in HDL, particularly triglyceride enrichment and altered apolipoprotein A-I structure, contribute to dysfunction.
Therapeutic strategies should focus on managing hypertriglyceridemia to improve HDL function.