Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diabetic cardiomyopathy.

Ankur A Karnik1, Anjali V Fields, Richard P Shannon

  • 1Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Current Hypertension Reports
|March 28, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Year in Review: Atrial Fibrillation 2025.

The Journal of innovations in cardiac rhythm management·2026
Same author

Multimodal quality improvement project on reducing hospital perioperative thromboembolic events (Patient Safety Indicator-12).

BMJ open quality·2025
Same author

A Year in Review: Atrial Fibrillation 2024.

The Journal of innovations in cardiac rhythm management·2025
Same author

Interactive visualization tool to understand and monitor health disparities in diabetes care and outcomes.

Journal of clinical and translational science·2024
Same author

Incorporating Acute Conditions into Risk-Adjustment for Provider Profiling: The Case of the US News and World Report Best Hospitals Rankings Methodology.

American journal of medical quality : the official journal of the American College of Medical Quality·2024
Same author

A Year in Review: Atrial Fibrillation 2023.

The Journal of innovations in cardiac rhythm management·2024
Same journal

Neural Control of Tissue Perfusion: Emerging Evidence and Beyond.

Current hypertension reports·2026
Same journal

Correction to: Should Incretin Agonist-Based Drugs be Considered for First Line Antihypertensive Therapy?

Current hypertension reports·2026
Same journal

Intersection of Pediatric Hypertension and Cardiovascular-Kidney-Metabolic Disease.

Current hypertension reports·2026
Same journal

Combined Aldosterone Synthase and SGLT2 Inhibition: A Recipe for Success in CKD with Uncontrolled Blood Pressure?

Current hypertension reports·2026
Same journal

Leveraging the Electronic Health Record to Identify and Manage Resistant Hypertension.

Current hypertension reports·2026
Same journal

Should Incretin Agonist-Based Brugs be Considered for First Line Antihypertensive Therapy?

Current hypertension reports·2026
See all related articles

Diabetic cardiomyopathy causes heart dysfunction even without coronary artery disease. Management should target insulin resistance and substrate metabolism alongside standard therapies.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Diseases

Background:

  • Diabetes mellitus is a significant risk factor for atherosclerosis and ischemic heart disease.
  • Diabetic cardiomyopathy, characterized by cardiac dysfunction independent of coronary atherosclerosis, is increasingly recognized.
  • Cardiac structural changes and impaired ventricular function occur even in well-controlled diabetes.

Purpose of the Study:

  • To review the mechanisms and clinical implications of diabetic cardiomyopathy.
  • To highlight the cardiac phenotype in diabetes beyond macrovascular complications.
  • To discuss potential therapeutic strategies for diabetic heart disease.

Main Methods:

  • Literature review of studies on diabetes and cardiac function.

Related Experiment Videos

  • Analysis ofPathophysiological mechanisms linking diabetes to cardiac dysfunction.
  • Synthesis of current understanding of diabetic cardiomyopathy.

    • Main Results:

    • Diabetes accelerates atherosclerosis and ischemic heart disease.
    • Diabetic cardiomyopathy involves ventricular remodeling and systolic/diastolic dysfunction.
    • Insulin resistance, hyperglycemia, and altered fatty acid metabolism contribute to cardiac dysfunction via microvascular disease and autonomic dysfunction.

    Conclusions:

    • Diabetic cardiomyopathy presents a distinct cardiac phenotype in diabetes.
    • Targeted therapies addressing insulin resistance and substrate metabolism are crucial.
    • Integrated management combining standard cardiovascular care with diabetes-specific cardiac interventions is recommended.