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Updated: Jul 6, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

Chemotherapy-induced peripheral neuropathy.

Bushra Malik¹, Mark Stillman

¹Section of Headache and Pain, Department of Neurology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. stillmm@ccf.org

Current Neurology and Neuroscience Reports

|March 28, 2008

Summary

Chemotherapy advances improve survival but can cause delayed nervous system damage. This neurotoxicity primarily affects the peripheral nerves, leading to chemotherapy-induced peripheral neuropathy.

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Last Updated: Jul 6, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

Area of Science:

Oncology
Neuroscience
Pharmacology

Background:

Chemotherapy has significantly improved survival rates for malignant diseases.
Therapy-induced toxicities, particularly neurotoxicity, pose a significant challenge.
Chemotherapy-induced neurotoxicity often presents with delayed onset and progressive nature.

Purpose of the Study:

To summarize the impact of chemotherapy on the nervous system.
To highlight the mechanisms of chemotherapy-induced neurotoxicity.
To define chemotherapy-induced peripheral neuropathy.

Main Methods:

Review of recent advances in chemotherapy development and administration.
Analysis of the toxicological effects of chemotherapy on the nervous system.
Examination of the specific targets within the peripheral nervous system.

Main Results:

Prolonged patient survival is a key outcome of modern chemotherapy.
The nervous system is a common target for chemotherapy-induced toxicity.
Chemotherapy-induced peripheral neuropathy affects neuronal cell bodies, axonal transport, and myelin sheaths.

Conclusions:

Despite improved survival, chemotherapy carries the risk of neurotoxicity.
Chemotherapy-induced peripheral neuropathy is a significant adverse effect impacting quality of life.
Understanding these toxicities is crucial for managing long-term cancer survivorship.