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Related Concept Videos

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jul 6, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Behavioral phenotyping strategies for mutant mice.

Jacqueline N Crawley1

  • 1Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892-3730, USA. crawleyj@intra.nimh.nih.gov

Neuron
|March 28, 2008
PubMed
Summary

Mouse behavioral phenotyping has advanced to improve gene function discovery in the brain. This review covers experimental design, high-throughput testing, and translational tools for analyzing mutant mouse behavior.

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Last Updated: Jul 6, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)
12:18

Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)

Published on: April 23, 2015

Light/dark Transition Test for Mice
10:35

Light/dark Transition Test for Mice

Published on: November 13, 2006

Area of Science:

  • Neuroscience
  • Genetics
  • Behavioral Science

Background:

  • Transgenic and knockout mice are crucial for understanding gene function in the brain.
  • Mouse behavioral phenotyping strategies have evolved significantly over the last decade.
  • Improved methods enhance the scope, replicability, and translational value of findings.

Purpose of the Study:

  • To review advancements in mouse behavioral phenotyping strategies.
  • To address experimental design considerations for robust research.
  • To provide examples of behavioral testing paradigms.

Main Methods:

  • Review of experimental design principles in behavioral phenotyping.
  • Examples of high-throughput behavioral batteries.
  • Description of learning, memory, and anxiety-related behavioral tests.

Main Results:

  • Evolved strategies maximize scope and replicability of findings.
  • Methods minimize procedural artifacts for clearer interpretation.
  • Phenotyping provides robust translational tools for hypothesis testing and treatment development.

Conclusions:

  • Advanced mouse behavioral phenotyping is essential for neuroscience research.
  • Standardized and validated methods are key for reliable results.
  • This primer offers guidance for researchers utilizing mouse models.