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Updated: Jul 6, 2026

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
Published on: April 21, 2022
Microarray analysis in sperm from fertile and infertile men without basic sperm analysis abnormalities reveals a
N Garrido1, J A Martínez-Conejero, J Jauregui
1Instituto Valenciano de Infertilidad, Universidad de Valencia, Valencia, Spain. nicolas.garrido@ivi.es
Abstract:
Sperm analysis following World Health Organization guidelines is unable to explain the molecular causes of male infertility when basic sperm parameters are within a normal range and women do not present gynecologic pathology. Consequently, there is a need for accurate diagnostic tools in this area, and microarray technology emerges as promising. We present, for the first time, preliminary results of a comparison of sperm mRNA expression profiles between fertile and infertile men with normal semen parameters, discovering profound discrepancies between groups, with potential diagnostic and therapeutic possibilities.
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