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Identification of a previously unrecognized production site of human renin

M S Seo¹, A Fukamizu, T Saito

¹Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.

Biochimica Et Biophysica Acta

|December 2, 1991

Abstract:

We found expression of the renin gene in the intestine of human, mouse and the transgenic mouse in which the 3' flanking sequences of the human renin gene function as a tissue-specific promoter. A cotransfection analysis showed that the promoter is activated by the product of adenovirus E1A 13S mRNA in cells originated from extrarenal tissues.

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