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Topiramate associated hypohidrosis and hyperthermia

Faruk Incecik1, M Ozlem Hergüner, Sakir Altunbasak

  • 1Cukurova University Medical Faculty, Department of Pediatric Neurology, Adana, Turkey. fincecik@yahoo.com

Indian Pediatrics
|March 28, 2008
PubMed

Insights

Topiramate, an antiepileptic drug, can cause decreased sweating (hypohidrosis) and high body temperature (hyperthermia) in children. This study highlights these potential adverse effects in pediatric epilepsy patients.

Area of Science:

  • Neurology
  • Pediatric Epilepsy
  • Pharmacovigilance

Background:

  • Topiramate is an established antiepileptic medication for partial onset and refractory seizures.
  • While generally well-tolerated in pediatric populations, potential adverse effects require monitoring.
  • Hypohidrosis and hyperthermia are known, albeit uncommon, side effects associated with topiramate therapy.

Observation:

  • This report details two pediatric cases of epilepsy treated with topiramate.
  • Both patients exhibited the development of hypohidrosis and hyperthermia during their treatment course.
  • These symptoms emerged during the administration of topiramate for seizure management.

Findings:

  • The study identifies a correlation between topiramate use and the occurrence of hypohidrosis and hyperthermia in children.
  • The observed adverse events suggest a need for increased clinical vigilance in pediatric patients on topiramate.
  • This reinforces the importance of recognizing and managing these specific side effects.

Implications:

  • Clinicians should be aware of the risk of hypohidrosis and hyperthermia when prescribing topiramate to children.
  • Early recognition and management of these adverse effects are crucial for patient safety.
  • Further research may be warranted to elucidate the mechanisms and prevalence of these side effects in pediatric populations.

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