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Related Experiment Videos

Circulating mononuclear cell numbers and function during intense exercise and recovery.

C J Field1, R Gougeon, E B Marliss

  • 1McGill Nutrition and Food Science Centre, Royal Victoria Hospital, Montreal, Quebec, Canada.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|September 1, 1991
PubMed
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Intense exercise temporarily alters immune cell counts and function, with some returning to normal quickly. These changes may impact immune system health and clinical outcomes.

Area of Science:

  • Exercise immunology
  • Cellular immunology

Background:

  • Intense exercise can transiently affect immune function.
  • Understanding these acute changes is crucial for assessing immune system health.

Purpose of the Study:

  • To investigate the acute effects of intense exercise on immune cell numbers and function.
  • To explore the relationship between exercise-induced immune changes and plasma epinephrine.

Main Methods:

  • Healthy males performed cycle exercise to exhaustion.
  • Blood samples were collected pre-exercise, at exhaustion, and during recovery.
  • Immune cell counts, phenotypes, and in vitro functional assays were performed.

Main Results:

  • Total leukocytes and neutrophils increased significantly post-exercise.

Related Experiment Videos

  • Natural killer cells increased, while T-helper cells decreased during exercise.
  • In vitro immune cell responses showed transient decreases in mitogenic response but increased cytotoxicity.

    • Conclusions:

    • Intense exercise induces significant acute alterations in circulating immune cell populations and function.
    • These changes may be linked to plasma epinephrine levels.
    • The findings suggest potential functional and clinical implications for the immune system post-exercise.