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Related Experiment Video

Updated: Jul 6, 2026

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

A case of serendipity*.

¹Department of Pharmacological and Physiological Sciences, St. Louis University Medical Center, St. Louis, MO, 63104, USA, FORRESMT@SLU.EDU.

Purinergic Signalling

|March 28, 2008

Summary

Adenosine triphosphate (ATP) is released from active muscle and influences cells externally. This extracellular ATP has potential roles in exercise, cancer therapy, and aging.

Area of Science:

Biochemistry
Cell Biology
Physiology

Background:

Acetylcholine bioassays unexpectedly identified adenosine triphosphate (ATP) release from skeletal muscle.
This discovery led to the broader concept of extracellular ATP influencing cell function.

Purpose of the Study:

To explore the release and function of extracellular adenosine triphosphate (ATP).
To investigate ATP's role in various physiological and pathological conditions.

Main Methods:

Utilized a sensitive bioassay system for neurotransmitter measurement.
Applied identification procedures to exercising human muscle, cardiac cells, and hypoxic erythrocytes.

Main Results:

Confirmed ATP release from active skeletal muscle in vitro and in vivo.

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Rare Event Detection Using Error-corrected DNA and RNA Sequencing

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Demonstrated ATP's extracellular influence on cell function across different cell types and conditions.

Discussed ATP release mechanisms triggered by mechanical distortion, depolarization, and hypoxia.

Conclusions:

Extracellular ATP is a signaling molecule with diverse physiological roles.
Potential therapeutic applications of extracellular ATP in cancer, radiation therapy, and aging warrant further investigation.
Extracellular ATP released from muscle during exercise may have local and distant effects.