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[Para-infectious seizures in children: a retrospective study of 34 cases]
J Lara-Herguedas1, J J García-Peñas, M L Ruiz-Falcó
1Servicio de Neurología, Hospital Infantil Universitario Niño Jesús, Madrid, España. larajulian@hotmail.com
Insights
Para-infectious seizures, linked to common infections, typically present in young children and have a good prognosis. Recurrent seizures are uncommon, and the risk of developing epilepsy is low.
Area of Science:
- Pediatric Neurology
- Infectious Diseases
- Epilepsy Research
Context:
- Para-infectious seizures are afebrile convulsions associated with common infections in children.
- These seizures often have a favorable prognosis.
- Distinguishing them from other seizure types, like febrile seizures, is crucial for accurate diagnosis and management.
Purpose:
- To investigate the natural history of para-infectious seizures in a pediatric cohort.
- To identify associated factors, clinical presentation, and long-term outcomes.
- To inform clinical practice and differentiate from more severe neurological conditions.
Summary:
- A retrospective study analyzed 34 children (6-38 months) with para-infectious seizures linked to infections like gastroenteritis or respiratory infections.
- Most children had normal psychomotor development, with a low incidence of recurrent seizures (23.5%) or subsequent epilepsy.
- The average interval from infection onset to seizures was 2.26 days, with an average of 3.38 seizures per patient.
Impact:
- Highlights the generally benign nature of para-infectious seizures, contrasting with initial concerns of encephalitic syndromes.
- Emphasizes the importance of recognizing these seizures, particularly in cases of gastroenteritis.
- Provides evidence for a low risk of developmental epilepsy following para-infectious seizures, aiding in parental counseling and clinical management.
Introduction:
Para-infectious seizures are afebrile convulsions that are associated with banal infectious processes and have a good overall prognosis.
Aim:
To determine the natural history of para-infectious seizures in children.
Patients And Methods:
We conducted a retrospective study of children who were admitted to our hospital between January 2000 and January 2005 with seizures associated to an infectious process that did not satisfy the criteria of febrile seizures. Data collected included age, sex, season of the year, personal and familial history, type of infection, symptoms of the seizures, complementary examinations, treatments that were used and progression.
Results:
The sample finally included 22 girls and 12 boys with ages ranging from 6 to 38 months (mean: 20.26 +/- 8.29 months) and previous psychomotor development was seen to be normal. Three of them had a family history of epilepsy and three others had suffered previous febrile seizures. Twenty-three children developed seizures associated to gastroenteritis and in 11 cases they were linked to upper respiratory infections. The average interval between onset of the infection and seizures was 2.26 days, and the average number of seizures was 3.38. Eight patients had recurring seizures (23.5%), usually in the form of para-infectious or febrile seizures, and secondary seizures were observed in only one case.
Conclusions:
It is important to be familiar with this condition because many of these patients are initially diagnosed with an encephalitic syndrome. These seizures are usually associated with gastroenteritis, with cluster seizures and with normal later psychomotor development. The risk of developing secondary seizures developmentally is low.
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