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Related Concept Videos

Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Microbiome of the Eye01:22

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...

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Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
05:26

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Published on: March 1, 2024

Ocular candidiasis: a review.

C P Shah1, J McKey, M J Spirn

  • 1Wills Eye Institute, 840 Walnut Street, Suite 800, Philadelphia, PA 19107, USA. cshah@post.harvard.edu

The British Journal of Ophthalmology
|March 29, 2008
PubMed
Summary
This summary is machine-generated.

Ocular candidiasis affects nearly 8% of inpatient candidaemia cases, with symptoms being a key risk factor. Early retinal exams and systemic antifungal treatment are crucial for managing this eye infection.

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Mycology

Background:

  • Inpatient candidaemia (bloodstream infection with Candida) is increasing.
  • Ocular candidiasis is a serious complication requiring prompt diagnosis and treatment.

Purpose of the Study:

  • To review ocular candidiasis epidemiology, diagnosis, and treatment.
  • To determine current prevalence and risk factors in an inpatient hospital setting.

Main Methods:

  • Retrospective review of inpatient ophthalmology consultations for candidaemia.
  • Systematic literature review using PubMed with keywords related to Candida and ocular infections.

Main Results:

  • Ocular candidiasis (chorioretinitis) was present in 7.9% of candidaemia consultations.
  • Patient-reported or un-reportable symptoms were significantly associated with ocular candidiasis risk.
  • Candida albicans was the most common species identified in ocular cases.

Conclusions:

  • Increasing candidaemia necessitates awareness of ocular involvement risks.
  • Symptom presence and Candida albicans are key risk factors for ocular candidiasis.
  • Systemic antifungal therapy is recommended; intravitreal or surgical options may be needed for severe cases.