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Annexin-A1 gene expression during liver development and post-translation modification after experimental endotoxemia
A S Damazo1, R J Flower, E Solito
1Department of Biology, Instituto de Biociências, Letras e Ciências Exatas , São Paulo State University - UNESP, São José do Rio Preto, SP, 15054-000, Brazil. asdamazo@ibilce.unesp.br
Objective And Design:
We have previously reported a role for annexin-A1 in liver proliferation and tumorogenicity as well as its action as an acute phase protein in a model of endotoxemia in interleukin-6 null mice.
Material And Methods:
In this study, we have investigated the analysis of the gene and protein expression in annexin-A1 null mice and the wild type livers during foetal and adult life, and in the presence of a proinflammatory stimulus.
Results:
The data indicate a link between the expression of the annexin-A1 as serine-phosphorylated-protein during early events of the inflammatory response and as tyrosine-phosphorylated-form at later time-points, during the resolution of inflammation.
Conclusions:
The study of annexin-A1 post-translation modification may promote a new annexin-A1 peptide discovery programme to treat specific pathologies.
