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Related Experiment Videos

Radiocontrast increases plasma and urinary endothelin.

K B Margulies1, F L Hildebrand, D M Heublein

  • 1Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905.

Journal of the American Society of Nephrology : JASN
|November 11, 1991
PubMed
Summary

Radiocontrast media increases endothelin (ET) levels, impacting kidney function. Atrial natriuretic factor (ANF) did not alter ET levels but preserved glomerular filtration rate (GFR) in a canine model of radiocontrast-induced nephropathy.

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Area of Science:

  • Nephrology
  • Cardiovascular Physiology
  • Pharmacology

Background:

  • Endothelin (ET) is a potent vasoconstrictor implicated in acute renal dysfunction.
  • Radiocontrast-induced nephropathy (RCIN) involves renal hemodynamic changes.
  • Atrial natriuretic factor (ANF) has shown potential in attenuating early renal responses to radiocontrast.

Purpose of the Study:

  • To investigate if intravenous radiocontrast increases endogenous plasma and urinary ET in a canine model of RCIN.
  • To determine if intra-aortic ANF modulates these ET responses.
  • To assess the effect of ANF on renal function during RCIN.

Main Methods:

  • Pacing-induced heart failure was induced in dogs.
  • Intravenous radiocontrast was administered with and without intra-aortic ANF infusion.

Related Experiment Videos

  • Plasma and urinary ET levels were measured.
  • Glomerular filtration rate (GFR) was monitored.

    • Main Results:

    • Intravenous radiocontrast significantly increased plasma and urinary ET levels.
    • Coadministration of ANF did not prevent the increase in ET levels.
    • ANF preserved acute renal function, maintaining GFR above baseline levels despite radiocontrast administration.

    Conclusions:

    • Radiocontrast administration leads to increased endogenous endothelin.
    • Atrial natriuretic factor does not inhibit ET release in response to radiocontrast.
    • ANF effectively preserves renal function in this RCIN model, highlighting its potential therapeutic role.